Chemical Name: Atomoxetine
Brand name: Strattera
What is Atomoxetine?
Atomoxetine, sold under the brand name Strattera, is a selective norepinephrine reuptake inhibitor (SNRI) that is not classified as a stimulant. Unlike stimulants like Modafinil and Armodafinil (Artvigil), which increase central nervous system activity and have the potential for euphoric effects and high addiction, SNRIs enhance serotonin and norepinephrine levels with minimal addiction risk, making them approved for medical use.
What is Atomoxetine used for?
Atomoxetine is primarily used to treat ADHD (Attention Deficit Hyperactivity Disorder), a condition characterized by difficulties with attention, hyperactivity, and impulsivity. It is preferred for treating ADHD due to its relatively low abuse potential. Atomoxetine can be used alone or alongside other prescription stimulants. Off-label, it is also utilized to treat mood disorders, eating disorders, cognitive dysfunction, and addictions.
What is the mechanism of action?
Atomoxetine is mainly prescribed for ADHD (Attention Deficit Hyperactivity Disorder), a chronic condition that causes attention difficulties, hyperactivity, and impulsivity. It is often preferred for ADHD due to its low abuse potential. Atomoxetine can be used alone or alongside other prescription stimulants. Off-label, it is also used to treat mood disorders, eating disorders, cognitive dysfunction, and addictions.
What are the approved strengths and doses?
Atomoxetine is available in strengths of 10mg, 18mg, 25mg, 40mg, 60mg, 80mg, and 100mg. The dosing is as follows:
For children and adults weighing up to 70 kg, the starting daily dose is 0.5 mg/kg. This can be increased within 3 days to a total dose of 1.2 mg/kg, either as one dose or split into two doses.
For children and adults over 70 kg, the starting dose is 40 mg daily, increased within 3 days to 80 mg daily. If necessary, the dose can be further increased to 100 mg over the next 2-4 weeks for patients who haven’t reached an optimal response.
What are Atomoxetine’s side effects?
common side effects :- include nausea, vomiting, diarrhea, headache, dizziness, loss of appetite, gastrointestinal problems, muscle pain, sweating, hot flashes, and tingling sensations in hands and feet.
Rare side effects:- yellowing of skin or eyes, difficulty swallowing or breathing, hives, itchy skin, flu-like symptoms, seizures, fast or irregular heartbeat, slurred speech, hallucinations, mood swings, decreased sex drive, and irregular menstrual periods.
Precautionary Measures:
Inform your doctor if you have any allergies to Atomoxetine.
Before using this medication, let your doctor know if you have any pre-existing health conditions such as glaucoma, heart problems, mental or mood disorders, liver issues, high blood pressure, etc.
Atomoxetine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery after taking this medication.
Long-term use of Atomoxetine in children can impact growth, weight, and other physical developments.
The medication should be used cautiously by pregnant women.
It is unclear whether Atomoxetine passes into breast milk, so consult your doctor if breastfeeding.
Rare Side Effects:
Yellowing of the skin or eyes, difficulty swallowing or breathing, hives, itchy skin, flu-like symptoms, seizures, fast or irregular heartbeat, slurred speech, hallucinations, mood swings, decreased sex drive, and irregular menstrual periods.
Drug Interactions with Atomoxetine:
MAO Inhibitors: Medicines like moclobemide, rasagiline, tranylcypromine, and linezolid can interfere with Atomoxetine. These should not be taken at least two weeks before or after treatment with Atomoxetine to avoid serious side effects.
Cough and Cold Medications: Certain medicines for treating coughs and colds may increase heart rate and/or blood pressure. These should be used cautiously alongside Atomoxetine.
Atomoxetine Pricing and Insurance Coverage in Canada:
Atomoxetine is available in both branded (Strattera) and generic forms in Canada. The branded version tends to be more expensive, while the generic is more affordable and generally covered by Medicare and most insurance plans.
Coverage depends on the following factors:
Your health insurance plan: The type of plan you have can influence coverage.
Formulary tier: Atomoxetine is placed in tier 4 of 5 tiers. Medications in higher tiers usually come with higher out-of-pocket costs for the patient.
Quantity limits: Some insurance companies may impose limits on how much Atomoxetine can be dispensed.
FAQ's
How long does Atomoxetine take to start working?
You might start noticing improvements in your symptoms within the first week of treatment. However, it may take up to a month to experience the full benefits.
How long does Atomoxetine stay in your system?
The medicine stays in your system for about 5.2 hours to 21.6 hours.
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